Asukamycin

• CAT Number: R003874
• CAS Number: 61116-33-4
• Molecular Formula: C31H34N2O7
• Molecular Weight: 546.62
• Purity: 95%
• Synonyms: AM1042;Asukamycin A
• Target: PROTAC
• Appearance: Yellow-brown solid
• Storage: -20°C
• Analysis method: HPLC
• IUPAC Name: (2E,4E,6E)-7-cyclohexyl-N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-7-oxohepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]hepta-2,4,6-trienamide
• InChI: InChI=1S/C31H34N2O7/c34-23-17-18-24(35)27(23)33-26(37)16-10-3-4-11-19-31(39)20-22(28(38)29-30(31)40-29)32-25(36)15-9-2-1-6-12-21-13-7-5-8-14-21/h1-4,6,9-12,15-16,19-21,29-30,34,39H,5,7-8,13-14,17-18H2,(H,32,36)(H,33,37)/b2-1+,4-3+,12-6+,15-9+,16-10+,19-11+/t29-,30-,31+/m1/s1
• InChIKey: SSHVAUUEPNULMP-JHWDTTIQSA-N
• SMILES: C1CCC(CC1)C=CC=CC=CC(=O)NC2=CC(C3C(C2=O)O3)(C=CC=CC=CC(=O)NC4=C(CCC4=O)O)O

Asukamycin is a type of antibiotic belonging to the ansamycin family, produced by the bacterium Streptomyces nodosus. It is known for its potent antibacterial activity, particularly against Gram-positive bacteria. Asukamycin works by inhibiting bacterial RNA synthesis, which disrupts protein production and leads to cell death. In addition to its antibiotic properties, asukamycin has also shown potential as an antitumor agent due to its ability to inhibit the heat shock protein 90 (Hsp90), a molecular chaperone involved in cancer cell survival. Its unique mechanism of action and chemical structure make it a valuable compound in both antibacterial and anticancer research.