For research use only. Not for therapeutic Use.
AT101(CAT: I005398), the R-(-) enantiomer of gossypol acetic acid, is a potent small-molecule inhibitor that binds to anti-apoptotic proteins Bcl-2, Bcl-xL, and Mcl-1. By disrupting the interaction of these proteins with pro-apoptotic factors, AT101 promotes the activation of the intrinsic apoptotic pathway, leading to tumor cell death. This compound has demonstrated efficacy in preclinical models of various cancers, including prostate, lung, and breast cancer. AT101 is widely used in research exploring the role of Bcl-2 family proteins in apoptosis regulation, cancer progression, and resistance mechanisms, as well as in developing targeted therapies for apoptosis-resistant malignancies.
| Catalog Number | I005398 |
| CAS Number | 90141-22-3 |
| Synonyms | 7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde |
| Molecular Formula | C30H30O8 |
| Purity | ≥95% |
| Target | Autophagy |
| Solubility | DMSO >80 mg/ml Ethanol >80 mg/ml |
| Storage | Store at -20°C |
| IC50 | 0.32/0.48/0.18 uM for Bcl-2/Bcl-xL/Mcl-1 |
| IUPAC Name | 7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde |
| InChI | InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3 |
| InChIKey | QBKSWRVVCFFDOT-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C |
