For research use only, not for therapeutic use.
AT-13387 (Cat No.:I005444) is a selective and potent inhibitor of heat shock protein 90 (Hsp90). Hsp90 is a chaperone protein that plays a crucial role in the folding, stabilization, and function of various client proteins involved in cell signaling and survival. By inhibiting Hsp90, AT-13387 disrupts the proper folding and stability of these client proteins, leading to their degradation and inhibition of their signaling pathways. This inhibition can potentially have anti-cancer effects by targeting multiple oncogenic pathways that depend on Hsp90 for proper functioning. AT-13387 has shown promise in preclinical studies and is being investigated as a potential therapeutic agent for various types of cancer.
Catalog Number | I005444 |
CAS Number | 912999-49-6 |
Synonyms | AT-13387 |
Molecular Formula | C₂₄H₃₁N₃O₃ |
Purity | ≥95% |
Target | HSP |
Solubility | DMSO: ≥ 33 mg/mL |
Storage | 3 years -20C powder |
IC50 | 18 nM |
Reference | <p> |