For research use only. Not for therapeutic Use.
Xevinapant（Cat No.:I006415）, also known as AT406, ARRY-334543, Debio1143, and SM-406, is a potent inhibitor of apoptosis protein (IAP) antagonist that acts through E3 ubiquitin ligase. It interacts with XIAP-BIR3, cIAP1-BIR3, and cIAP2-BIR3 with binding affinities (Ki) of 66.4 nM, 1.9 nM, and 5.1 nM, respectively. Notably, Xevinapant exhibits 50- to 100-fold higher affinity compared to the Smac AVPI peptide. This compound’s ability to inhibit IAPs makes it a promising candidate for therapeutic interventions targeting apoptosis dysregulation in various diseases.
| Catalog Number | I006415 |
| CAS Number | 1071992-99-8 |
| Synonyms | DeBio-1143; DeBio1143; DeBio 1143; AT-406; AT406; AT 406; SM 406; SM406; ARRY-334543; ARRY334543; ARRY 334543.;(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide |
| Molecular Formula | C₃₂H₄₃N₅O₄ |
| Purity | ≥95% |
| Target | IAP inhibitor |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at -20°C |
| IUPAC Name | (5S,8S,10aR)-N-benzhydryl-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide |
| InChI | InChI=1S/C32H43N5O4/c1-21(2)19-28(38)36-18-17-25-15-16-27(37(25)32(41)26(20-36)34-30(39)22(3)33-4)31(40)35-29(23-11-7-5-8-12-23)24-13-9-6-10-14-24/h5-14,21-22,25-27,29,33H,15-20H2,1-4H3,(H,34,39)(H,35,40)/t22-,25+,26-,27-/m0/s1 |
| InChIKey | LSXUTRRVVSPWDZ-MKKUMYSQSA-N |
| SMILES | CC(C)CC(=O)N1CCC2CCC(N2C(=O)C(C1)NC(=O)C(C)NC)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4 |
| Reference | </br>1:Hurwitz HI, Smith DC, Pitot HC, Brill JM, Chugh R, Rouits E, Rubin J, Strickler J, Vuagniaux G, Sorensen JM, Zanna C. Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study. Cancer Chemother Pharmacol. 2015 Apr;75(4):851-9. doi: 10.1007/s00280-015-2709-8. Epub 2015 Feb 27. PubMed PMID: 25716544; PubMed Central PMCID: PMC4365270. |
