AT-527

• CAT Number: I022587
• CAS Number: 2241337-84-6
• Molecular Formula: C48H68F2N14O18P2S
• Molecular Weight: 1261.16
• Purity: 98%
• Synonyms: AT 527; AT-527; AT527; RG 6422; RG-6422; RG6422
• Target: HCV
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-[2-amino-6-(methylamino)purin-9-yl]-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate;sulfuric acid
• InChI: InChI=1S/2C24H33FN7O7P.H2O4S/c2*1-13(2)37-21(34)14(3)31-40(35,39-15-9-7-6-8-10-15)36-11-16-18(33)24(4,25)22(38-16)32-12-28-17-19(27-5)29-23(26)30-20(17)32;1-5(2,3)4/h2*6-10,12-14,16,18,22,33H,11H2,1-5H3,(H,31,35)(H3,26,27,29,30);(H2,1,2,3,4)/t2*14-,16+,18+,22+,24+,40-;/m00./s1
• InChIKey: QIGYBLSWYRTXCA-NVSCJZCKSA-N
• SMILES: C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=NC3=C(N=C(N=C32)N)NC)(C)F)O)OC4=CC=CC=C4.C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=NC3=C(N=C(N=C32)N)NC)(C)F)O)OC4=CC=CC=C4.OS(=O)(=O)O

AT-527（Cat No.:I022587）is a guanosine nucleotide analog that exhibits potent antiviral activity against a range of RNA viruses, including SARS-CoV-2. It acts by inhibiting the viral RNA polymerase, thereby disrupting viral replication. Designed for oral administration, AT-527 offers a promising approach for treating COVID-19 and other RNA virus infections. Its favorable pharmacokinetic profile and broad-spectrum antiviral properties position it as a significant candidate in antiviral therapy. Ongoing studies explore its efficacy, safety, and potential as a treatment or prophylactic agent in pandemic preparedness and viral disease management.

Reference

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