AT7519 trifluoroacetate

• CAT Number: I001661
• CAS Number: 1431697-85-6
• Molecular Formula: C18H18Cl2F3N5O4
• Molecular Weight: 496.27
• Purity: ≥95%
• Synonyms: 4-[(2,6-dichlorobenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamide;2,2,2-trifluoroacetic acid
• Target: Cyclin-Dependent Kinases
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 10-210 nM
• InChI: InChI=1S/C16H17Cl2N5O2.C2HF3O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9;3-2(4,5)1(6)7/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24);(H,6,7)
• InChIKey: XTOQTRBZWZONHQ-UHFFFAOYSA-N
• SMILES: C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl.C(=O)(C(F)(F)F)O

AT7519 trifluoroacetate(Cat No.:I001661) is a potent and selective small molecule inhibitor of cyclin-dependent kinases (CDKs) with potential anticancer activity. By inhibiting CDKs, AT7519 trifluoroacetate disrupts the cell cycle progression and leads to cell cycle arrest and apoptosis in cancer cells. It targets multiple CDKs, including CDK1, CDK2, CDK4, and CDK9, which are involved in regulating cell division and transcriptional regulation. AT7519 trifluoroacetate has demonstrated promising activity against a variety of cancer types in preclinical studies and is being investigated in clinical trials for its potential as an anticancer therapy.

Reference

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[5]. Wyatt PG, Woodhead AJ, Berdini V, Boulstridge JA, Carr MG, Cross DM, Davis DJ, Devine LA, Early TR, Feltell RE, Lewis EJ, McMenamin RL, Navarro EF, O/’Brien MA, O/’Reilly M, Reule M, Saxty G, Seavers LC, Smith DM, Squires MS, Trewartha G, Walker MT, Woolford AJ.Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.J Med Chem. 2008 Aug 28;51(16):4986-99. Epub 2008 Jul 26.