Ataciguat

• CAT Number: R009251
• CAS Number: 254877-67-3
• Molecular Formula: C21H19Cl2N3O6S3
• Molecular Weight: 576.478
• Purity: ≥95%
• Synonyms: 5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide; HMR 1766
• Target: Guanylate Cyclase
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 5-chloro-2-[(5-chlorothiophen-2-yl)sulfonylamino]-N-(4-morpholin-4-ylsulfonylphenyl)benzamide
• InChI: InChI=1S/C21H19Cl2N3O6S3/c22-14-1-6-18(25-34(28,29)20-8-7-19(23)33-20)17(13-14)21(27)24-15-2-4-16(5-3-15)35(30,31)26-9-11-32-12-10-26/h1-8,13,25H,9-12H2,(H,24,27)
• InChIKey: PQHLRGARXNPFCF-UHFFFAOYSA-N
• SMILES: C1COCCN1S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=C(C=CC(=C3)Cl)NS(=O)(=O)C4=CC=C(S4)Cl

Ataciguat, also known as HMR-1766, is a potent guanylate cyclase activator potentially for the treatment of aortic valve stenosis. HMR-1766 is a promising agent for treating diseases associated with increased vascular tone combined with enhanced ROS production. Ataciguat improves vascular function and reduces platelet activation in heart failure.

Reference

1:Comparative Relaxant Effects of Ataciguat and Zaprinast on Sheep Sphincter of Oddi. Çakmak E, Yönem Ö, Saraç B, Parlak M, Çelik C, Ataseven H, Bağcivan İ.Balkan Med J. 2016 Jul;33(4):453-7. doi: 10.5152/balkanmedj.2016.15400. Epub 2016 Jul 1. PMID: 27606143 Free PMC Article2:Guanylyl cyclase activator ataciguat improves vascular function and reduces platelet activation in heart failure. Schäfer A, Fraccarollo D, Werner L, Bauersachs J.Pharmacol Res. 2010 Nov;62(5):432-8. doi: 10.1016/j.phrs.2010.06.008. Epub 2010 Jun 22. PMID: 20600916 3:Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress. Zhou Z, Pyriochou A, Kotanidou A, Dalkas G, van Eickels M, Spyroulias G, Roussos C, Papapetropoulos A.Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1763-71. doi: 10.1152/ajpheart.51.2008. Epub 2008 Aug 29. PMID: 18757489 Free Article