Atenolol

• CAT Number: I003014
• CAS Number: 29122-68-7
• Molecular Formula: C14H22N2O3
• Molecular Weight: 266.34
• Purity: ≥95%
• Synonyms: 2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
• InChI: InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)
• InChIKey: METKIMKYRPQLGS-UHFFFAOYSA-N
• SMILES: CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O

Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris[1][2].
Atenolol (1-100 μM, 5 h) strengthenes the inhibitory effect on cell migration of rat aortic smooth muscle cells when combinated with Nifedipine (HY-B0284) (1-100μM)[3].
Atenolol (50-150 μM, 24 h) decreases the cell surival of Hem-ECs in a dose-dependent manner[4].
Atenolol (5-20 mg/kg, i.g., one time) combinated with Amlodipine (HY-B0317) can reduce and stabilize blood oressure (BP) in 2K1C renovascular hypertensive rats[5].
Atenolol (6 mg/kg, p.o., one time) combinated with Nifedipine (HY-B0284) prevents ZD6126-induced cardiac necrosis and increases plasma troponin T levels[6].
Atenolol (40 mg/kg, p.o., daily, 6 weeks) increased plasma membrane β1- and β2- adrenoceptors density in rats[7].

Reference

[1]. Heel RC, et al. Atenolol: a review of its pharmacological properties and therapeutic efficacy in angina pectoris and hypertension. Drugs. 1979;17(6):425-460.
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[2]. Engel G, et al. (+/-)[125Iodo] cyanopindolol, a new ligand for beta-adrenoceptors: identification and quantitation of subclasses of beta-adrenoceptors in guinea pig. Naunyn Schmiedebergs Arch Pharmacol. 1981;317(4):277-285.
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[3]. Corsini A, et al. Effect of the nifedipine-atenolol association on arterial myocyte migration and proliferation. Pharmacol Res. 1993 May-Jun;27(4):299-307.
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[4]. Lorusso B, et al. Β-blockers activate autophagy on infantile hemangioma-derived endothelial cells in vitro. Vascul Pharmacol. 2022 Oct;146:107110
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[5]. Shen FM, et al. Synergistic effects of atenolol and amlodipine for lowering and stabilizing blood pressure in 2K1C renovascular hypertensive rats. Acta Pharmacol Sin. 2005 Nov;26(11):1303-8.
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[6]. Gould S, et al. Effect of pretreatment with atenolol and nifedipine on ZD6126-induced cardiac toxicity in rats. J Natl Cancer Inst. 2007 Nov 21;99(22):1724-8.
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[7]. Horinouchi T, et al. Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol. Life Sci. 2007 Jul 12;81(5):399-404.
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