For research use only. Not for therapeutic Use.
ATG7-IN-1 is a potent and selective inhibitor of ATG7 (IC50 = 62 nM).
| Catalog Number | I045145 |
| CAS Number | 2226229-87-2 |
| Synonyms | [(2S,3S,5R)-5-[4-amino-3-(2-fluoro-4-methylphenyl)sulfanylpyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methyl sulfamate |
| Molecular Formula | C17H19FN6O5S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H19FN6O5S2/c1-8-2-3-12(9(18)4-8)30-17-14-15(19)21-7-22-16(14)24(23-17)13-5-10(25)11(29-13)6-28-31(20,26)27/h2-4,7,10-11,13,25H,5-6H2,1H3,(H2,19,21,22)(H2,20,26,27)/t10-,11-,13+/m0/s1 |
| InChIKey | GRYCCRMITKNCNZ-GMXVVIOVSA-N |
| SMILES | CC1=CC(=C(C=C1)SC2=NN(C3=NC=NC(=C32)N)C4CC(C(O4)COS(=O)(=O)N)O)F |
| Reference | [1]. Huang SC, et al. Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors. Bioorg Med Chem. 2020 Oct 1;28(19):115681. |
