Atipamezole hydrochloride

• CAT Number: I000238
• CAS Number: 104075-48-1
• Molecular Formula: C14H16N2 • HCl
• Molecular Weight: 248.8
• Purity: ≥95%
• Synonyms: 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride
• Target: Adrenergic Receptor
• Solubility: DMSO: ≥ 47 mg/mL
• Storage: Desiccate at RT
• InChI: InChI=1S/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H
• InChIKey: PCCVCJAQMHDWJY-UHFFFAOYSA-N
• SMILES: CCC1(C2=CN=CN2)CC3=CC=CC=C3C1.Cl

Atipamezole hydrochloride (CAT: I000238) is a selective alpha-2 adrenergic receptor antagonist used as a veterinary drug primarily in the field of veterinary anesthesia and sedation. It is commonly used as a reversal agent for the alpha-2 agonist sedatives such as medetomidine and dexmedetomidine in dogs and other animals. Atipamezole hydrochloride acts by competitively binding to and blocking the alpha-2 adrenergic receptors, reversing the sedative effects and restoring normal physiological functions. It is a valuable tool in veterinary medicine for quickly and safely reversing the effects of sedative medications.

Reference

1: Bush M, Raath JP, Phillips LG, Lance W. Immobilisation of impala (Aepyceros
melampus) with a ketamine hydrochloride/medetomidine hydrochloride combination,
and reversal with atipamezole hydrochloride. J S Afr Vet Assoc. 2004
Mar;75(1):14-8. PubMed PMID: 15214689.

2: Pettifer GR, Dyson DH, McDonell WN. An evaluation of the influence of
medetomidine hydrochloride and atipamezole hydrochloride on the arrhythmogenic
dose of epinephrine in dogs during halothane anesthesia. Can J Vet Res. 1996
Jan;60(1):1-6. PubMed PMID: 8825986; PubMed Central PMCID: PMC1263792.

3: Rioja E, Kerr CL, Enouri SS, McDonell WN. Sedative and cardiopulmonary effects
of medetomidine hydrochloride and xylazine hydrochloride and their reversal with
atipamezole hydrochloride in calves. Am J Vet Res. 2008 Mar;69(3):319-29. doi:
10.2460/ajvr.69.3.319. PubMed PMID: 18312129.