For research use only. Not for therapeutic Use.
Atorvastatin lactone is a prodrug form of atorvastatin (Item No. <span class=/itemid/>10493</span>), an HMG-CoA reductase inhibitor used to lower blood cholesterol levels. The lactone hydrolyzes rapidly to the acid form of atorvastatin in human serum at room temperature. Atorvastatin lactone can also be formed <em>in vivo</em> from atorvastatin by certain uridine 5’-diphospho-glucuronosyltransferases. Like atorvastatin, the lactone inhibits P-glycoprotein in a concentration-dependent manner.
| Catalog Number | R004661 |
| CAS Number | 125995-03-1 |
| Synonyms | 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide; Atorvastatin δ-Lactone; USP Atorvastatin Related Compound H |
| Molecular Formula | C33H33FN2O4 |
| Purity | ≥95% |
| Storage | -20°C |
| InChIKey | OUCSEDFVYPBLLF-KAYWLYCHSA-N |
