Atovaquone

• CAT Number: A000600
• CAS Number: 95233-18-4
• Molecular Formula: 95233-18-4; Mepron; Wellvone; Acuvel; 566C80
• Molecular Weight: 366.84
• Purity: ≥95%
• Synonyms: Atavaquone
• Target: Metabolic Enzyme/Protease
• Storage: -20°C
• IUPAC Name: 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione
• InChI: InChI=1S/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,24H,5-8H2
• InChIKey: BSJMWHQBCZFXBR-UHFFFAOYSA-N
• SMILES: C1CC(CCC1C2=CC=C(C=C2)Cl)C3=C(C4=CC=CC=C4C(=O)C3=O)O

Atovaquone（Cat No.:A000600）is an antiparasitic and antiprotozoal agent widely used for the prevention and treatment of infections such as Plasmodium falciparum malaria and Pneumocystis jirovecii pneumonia (PCP). It works by inhibiting the mitochondrial electron transport chain, specifically targeting cytochrome bc1 complex, disrupting energy production in susceptible organisms. With its oral bioavailability and favorable safety profile, Atovaquone is commonly combined with proguanil for malaria treatment, enhancing efficacy and reducing resistance risk. Its broad-spectrum activity and targeted mechanism make it a vital tool in managing opportunistic and parasitic infections.

Reference

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