For research use only. Not for therapeutic Use.
ATPA is a selective glutamate receptor GluR5 activator with EC50s of 0.66, 9.5, 1.4, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S741M), GluR5(S721T), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V), respectively[1].
ATPA also activates GluR1wt, GluR1(M722S), GluR1(T700S), GluR1(T700S, M722S), GluR1(M722A) with EC50s of 62, 4.6, 97, 14, 97 μM, respectively[1].
| Catalog Number | M091563 |
| CAS Number | 140158-50-5 |
| Synonyms | 2-amino-3-(5-tert-butyl-3-oxo-1,2-oxazol-4-yl)propanoic acid |
| Molecular Formula | C10H16N2O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H16N2O4/c1-10(2,3)7-5(8(13)12-16-7)4-6(11)9(14)15/h6H,4,11H2,1-3H3,(H,12,13)(H,14,15) |
| InChIKey | PIXJURSCCVBKRF-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=C(C(=O)NO1)CC(C(=O)O)N |
| Reference | [1]. Nielsen MM, et al. The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741. Mol Pharmacol. 2003 Jan;63(1):19-25. |
