For research use only. Not for therapeutic Use.
ATR Inhibitor 2（Cat No.:I015464）is a selective small-molecule inhibitor targeting the ataxia telangiectasia and Rad3-related (ATR) kinase, a crucial regulator of the DNA damage response. By inhibiting ATR, this compound disrupts the cell’s ability to repair damaged DNA, leading to cell cycle arrest and apoptosis, particularly in cancer cells with high replication stress. ATR Inhibitor 2 is widely used in cancer research to investigate novel therapeutic strategies that exploit DNA repair vulnerabilities in tumors, enhancing the effectiveness of chemotherapy and radiotherapy. It is valuable for developing targeted cancer treatments.
| Catalog Number | I015464 |
| CAS Number | 1613191-99-3 |
| Molecular Formula | C₂₅H₂₉F₂N₉O₃ |
| Purity | ≥95% |
| IUPAC Name | 2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)piperazine-1-carbonyl]piperidin-1-yl]pyridin-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide |
| InChI | InChI=1S/C25H29F2N9O3/c26-16-9-30-23-20(22(28)32-36(23)12-16)24(37)31-19-11-29-10-18(27)21(19)34-3-1-15(2-4-34)25(38)35-7-5-33(6-8-35)17-13-39-14-17/h9-12,15,17H,1-8,13-14H2,(H2,28,32)(H,31,37) |
| InChIKey | QAYHKBLKSXWOEO-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1C(=O)N2CCN(CC2)C3COC3)C4=C(C=NC=C4NC(=O)C5=C6N=CC(=CN6N=C5N)F)F |
| Reference | [1]. Frank T. Zenke, et al. Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy. Experimental and Molecular Therapeutics.<br>[2]. Gorecki L, et al. Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy. Pharmacol Ther. 2020 Feb 26:107518. |
