Atuzaginstat

• CAT Number: I022642
• CAS Number: 2211981-76-7
• Molecular Formula: C19H25F3N2O3
• Molecular Weight: 386.42
• Purity: 98%
• Synonyms: Atuzaginstat
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-[(3S)-7-amino-2-oxo-1-(2,3,6-trifluorophenoxy)heptan-3-yl]cyclopentanecarboxamide
• InChI: InChI=1S/C19H25F3N2O3/c20-13-8-9-14(21)18(17(13)22)27-11-16(25)15(7-3-4-10-23)24-19(26)12-5-1-2-6-12/h8-9,12,15H,1-7,10-11,23H2,(H,24,26)/t15-/m0/s1
• InChIKey: OLIMBXKACVCIMM-HNNXBMFYSA-N
• SMILES: O=C(C1CCCC1)N[C@@H](CCCCN)C(COC2=C(F)C=CC(F)=C2F)=O

Atuzaginstat(CAT: I022642) is a selective and potent inhibitor of lysine gingipain (Kgp), a cysteine protease produced by Porphyromonas gingivalis, a key pathogen implicated in periodontitis and Alzheimer’s disease. By targeting Kgp, Atuzaginstat reduces bacterial virulence, inflammation, and neurodegenerative processes associated with P. gingivalis infection. It has shown promise in preclinical and clinical studies for modulating systemic and local inflammation, particularly in periodontal and neuroinflammatory disorders. Atuzaginstat is a valuable tool for research into the role of bacterial proteases in disease progression and the development of therapeutic strategies for conditions linked to microbial dysbiosis.