AU1235

• CAT Number: I013549
• CAS Number: 1338780-86-1
• Molecular Formula: C₁₇H₁₉F₃N₂O
• Molecular Weight: 324.34
• Purity: ≥95%
• Target: Bacterial
• Solubility: DMSO: 6 mg/mL (need ultrasonic)
• Storage: Store at -20°C
• IUPAC Name: 1-(1-adamantyl)-3-(2,3,4-trifluorophenyl)urea
• InChI: InChI=1S/C17H19F3N2O/c18-12-1-2-13(15(20)14(12)19)21-16(23)22-17-6-9-3-10(7-17)5-11(4-9)8-17/h1-2,9-11H,3-8H2,(H2,21,22,23)
• InChIKey: PYDHHHKUANVSJV-UHFFFAOYSA-N
• SMILES: C1C2CC3CC1CC(C2)(C3)NC(=O)NC4=C(C(=C(C=C4)F)F)F

AU1235（Cat No.:I013549）is an adamantyl urea compound that demonstrates potent inhibitory activity against the Mycobacterium tuberculosis protein MmpL3. MmpL3 is an essential transporter involved in the biosynthesis of the mycobacterial cell wall, making it an attractive target for tuberculosis treatment. AU1235’s inhibitory effect on MmpL3 disrupts cell wall synthesis, leading to impaired bacterial growth and survival. As a promising inhibitor, AU1235 holds potential for the development of novel therapies against tuberculosis and combating drug-resistant strains of Mycobacterium tuberculosis.

Reference

[1]. Grzegorzewicz AE, et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012 Feb 19;8(4):334-41.