For research use only. Not for therapeutic Use.
Aucubin（Cat No.:I003683）is a naturally occurring iridoid glycoside found in plants such as Plantago asiatica and Eucommia ulmoides, valued for its diverse therapeutic properties. It exhibits significant anti-inflammatory, hepatoprotective, and antioxidant effects, making it a focus in traditional and modern medicine for conditions like liver disorders and inflammation. Aucubin also demonstrates potential in wound healing and immune modulation, as it supports cell regeneration and reduces oxidative stress. Its broad bioactivity profile has spurred research into its applications in pharmaceuticals and nutraceuticals for managing chronic diseases and promoting health.
| Catalog Number | I003683 |
| CAS Number | 479-98-1 |
| Molecular Formula | C15H22O9 |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | DMSO: ≥ 31 mg/mL |
| Storage | 2-8°C |
| IUPAC Name | (2S,3R,4S,5S,6R)-2-[[(1S,4aR,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol |
| InChI | InChI=1S/C15H22O9/c16-4-6-3-8(18)7-1-2-22-14(10(6)7)24-15-13(21)12(20)11(19)9(5-17)23-15/h1-3,7-21H,4-5H2/t7-,8+,9+,10+,11+,12-,13+,14-,15-/m0/s1 |
| InChIKey | RJWJHRPNHPHBRN-FKVJWERZSA-N |
| SMILES | C1=CO[C@H]([C@H]2[C@@H]1[C@@H](C=C2CO)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O |
| Reference | </br>1:The Protective Effect of Aucubin from Eucommia ulmoides Against Status Epilepticus by Inducing Autophagy and Inhibiting Necroptosis. Wang J, Li Y, Huang WH, Zeng XC, Li XH, Li J, Zhou J, Xiao J, Xiao B, Ouyang DS, Hu K.Am J Chin Med. 2017 Apr 7:1-17. doi: 10.1142/S0192415X17500331. [Epub ahead of print] PMID: 28387136 </br>2:Prophylactic Administration of Aucubin Inhibits Paclitaxel-Induced Mechanical Allodynia via the Inhibition of Endoplasmic Reticulum Stress in Peripheral Schwann Cells. Andoh T, Uta D, Kato M, Toume K, Komatsu K, Kuraishi Y.Biol Pharm Bull. 2017;40(4):473-478. doi: 10.1248/bpb.b16-00899. PMID: 28381802 Free Article</br>3:Aucubin and its hydrolytic derivative attenuate activation of hepatic stellate cells via modulation of TGF-β stimulation. Lv PY, Feng H, Huang WH, Tian YY, Wang YQ, Qin YH, Li XH, Hu K, Zhou HH, Ouyang DS.Environ Toxicol Pharmacol. 2017 Mar;50:234-239. doi: 10.1016/j.etap.2017.02.012. Epub 2017 Feb 8. PMID: 28199906 </br>4:Protective effects of aucubin on osteoarthritic chondrocyte model induced by hydrogen peroxide and mechanical stimulus. Young IC, Chuang ST, Hsu CH, Sun YJ, Liu HC, Chen YS, Lin FH.BMC Complement Altern Med. 2017 Feb 2;17(1):91. doi: 10.1186/s12906-017-1581-y. PMID: 28153003 Free PMC Article</br>5:Simultaneous Determination of Catalpol, Aucubin, and Geniposidic Acid in Different Developmental Stages of Rehmannia glutinosa Leaves by High Performance Liquid Chromatography. Wang Y, Liao D, Qin M, Li X.J Anal Methods Chem. 2016;2016:4956589. doi: 10.1155/2016/4956589. Epub 2016 Jun 26. PMID: 27429834 Free PMC Article</br>6:Prophylactic administration of an extract from Plantaginis Semen and its major component aucubin inhibits mechanical allodynia caused by paclitaxel in mice. Andoh T, Kato M, Kitamura R, Mizoguchi S, Uta D, Toume K, Komatsu K, Kuraishi Y.J Tradit Complement Med. 2016 Jan 2;6(3):305-8. doi: 10.1016/j.jtcme.2015.12.001. eCollection 2016 Jul. PMID: 27419098 Free PMC Article</br>7:In Vitro Effects of Plantago Major Extract, Aucubin, and Baicalein on Candida Albicans Biofilm Formation, Metabolic Activity, and Cell Surface Hydrophobicity. Shirley KP, Windsor LJ, Eckert GJ, Gregory RL.J Prosthodont. 2015 Nov 30. doi: 10.1111/jopr.12411. [Epub ahead of print] PMID: 26618515 </br>8:Pharmacokinetics and tissue distribution of Aucubin, Ajugol and Catalpol in rats using a validated simultaneous LC-ESI-MS/MS assay. Xue B, Ma B, Zhang Q, Li X, Zhu J, Liu M, Wu X, Wang C, Wu Z.J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:245-53. doi: 10.1016/j.jchromb.2015.08.026. Epub 2015 Aug 28. PMID: 26342167 </br>9:Aucubin prevents interleukin-1 beta induced inflammation and cartilage matrix degradation via inhibition of NF-κB signaling pathway in rat articular chondrocytes. Wang SN, Xie GP, Qin CH, Chen YR, Zhang KR, Li X, Wu Q, Dong WQ, Yang J, Yu B.Int Immunopharmacol. 2015 Feb;24(2):408-15. doi: 10.1016/j.intimp.2014.12.029. Epub 2015 Jan 6. PMID: 25576403 </br>10:Aucubin promotes neurite outgrowth in neural stem cells and axonal regeneration in sciatic nerves. Kim YM, Sim UC, Shin Y, Kim Kwon Y.Exp Neurobiol. 2014 Sep;23(3):238-45. doi: 10.5607/en.2014.23.3.238. Epub 2014 Sep 18. PMID: 25258571 Free PMC Article |
