For research use only. Not for therapeutic Use.
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-<wbr></wbr>7. It has anti-<wbr></wbr>inflammatory, anti-<wbr></wbr>carcinogenic, anti-<wbr></wbr>bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis. When examined for its potential use in Alzheimer’s disease treatment, auraptene was shown to inhibit β-<wbr></wbr>secretase (BACE1) activity with an IC<sub>50</sub> value of 345.1 μM.
CAS Number | 495-02-3 |
Synonyms | 7-[[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]oxy]-2H-1-benzopyran-2-one; 7-(Geranyloxy)-coumarin; 7-[(3,7-Dimethyl-2,6-octadienyl)oxy]-coumarin; (E)-7-Geranoxycoumarin; 7-Geranyloxycoumarin; Aurapten; Aurapten (C19H22O3); Auraptene; |
Molecular Formula | C19H22O3 |
Purity | ≥95% |
Target | MMP |
Storage | -20°C |
IUPAC Name | 7-[(2E)-3,7-dimethylocta-2,6-dienoxy]chromen-2-one |
InChI | InChI=1S/C19H22O3/c1-14(2)5-4-6-15(3)11-12-21-17-9-7-16-8-10-19(20)22-18(16)13-17/h5,7-11,13H,4,6,12H2,1-3H3/b15-11+ |
InChIKey | RSDDHGSKLOSQFK-RVDMUPIBSA-N |
SMILES | CC(=CCCC(=CCOC1=CC2=C(C=C1)C=CC(=O)O2)C)C |