Aureothricin

• CAT Number: R000141
• CAS Number: 574-95-8
• Molecular Formula: C9H10N2O2S2
• Molecular Weight: 242.31
• Purity: 98%
• Synonyms: N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolopyrrol-6-yl)-propanamide
• Target: Bacterial
• Appearance: Yellow orange solid
• Storage: -20°C
• Analysis method: HPLC
• IUPAC Name: N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)propanamide
• InChI: InChI=1S/C9H10N2O2S2/c1-3-6(12)10-7-8-5(4-14-15-8)11(2)9(7)13/h4H,3H2,1-2H3,(H,10,12)
• InChIKey: UGZYFXMSMFMTSM-UHFFFAOYSA-N
• SMILES: CCC(=O)NC1=C2C(=CSS2)N(C1=O)C

Aureothricin（Cat No.:R000141）is an antibiotic derived from Streptomyces species, notable for its activity against Gram-positive bacteria. As an early example of thiopeptide antibiotics, it functions by inhibiting protein synthesis, ultimately preventing bacterial growth. While it shows limited activity against Gram-negative bacteria, Aureothricin has been valuable in researching antibiotic mechanisms and in developing newer antibiotics with similar structures. Although less commonly used in clinical settings today due to newer antibiotics, it remains significant in the study of antimicrobial resistance and in pharmaceutical research on thiopeptide antibiotic efficacy.

Reference

1. Folia Microbiol (Praha). 1990;35(4):278-83.

Regulation of biosynthesis of thiolutin and aureothricin in Streptomyces
kasugaensis.

Sturdíková M(1), Proksa B, Uhrín D, Fuska J.

Author information:
(1)Department of Biochemical Technology, Faculty of Chemical Technology, Slovak
Technical University, Bratislava, Czechoslovakia.

L-Methionine and DL-ethionine decreased production of thiolutin and aureothricin
in Streptomyces kasugaensis. In the presence of L-methionine the culture also
produced 3-methylthioacrylic acid, 3-methylthiopropionic acid and
3,6-bis-(2-methylthioethyl)-2,5-dioxopiperazine. Production of the metabolites
depended on the concentration of L-methionine in the medium.