Aurora kinase inhibitor-8

• CAT Number: I027660
• CAS Number: 2133001-88-2
• Molecular Formula: C30H29N7O3
• Molecular Weight: 535.60
• Purity: ≥95%
• Synonyms: 4-(propanoylamino)-N-[4-[(5,8,11-trimethyl-6-oxopyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]benzamide
• InChI: InChI=1S/C30H29N7O3/c1-5-26(38)32-20-9-7-19(8-10-20)28(39)33-21-11-13-22(14-12-21)34-30-31-17-25-27(35-30)36(3)24-15-6-18(2)16-23(24)29(40)37(25)4/h6-17H,5H2,1-4H3,(H,32,38)(H,33,39)(H,31,34,35)
• InChIKey: KGXBCWANASZZQG-UHFFFAOYSA-N
• SMILES: CCC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)NC3=NC=C4C(=N3)N(C5=C(C=C(C=C5)C)C(=O)N4C)C

Aurora kinase inhibitor-8（Cat No.:I027660）is a potent small molecule compound designed to selectively inhibit Aurora kinases, a family of enzymes that play crucial roles in regulating cell division, particularly during mitosis. By blocking the activity of Aurora kinases, this inhibitor disrupts the proper formation and function of the mitotic spindle, leading to cell cycle arrest and inducing apoptosis in cancer cells. Aurora kinase inhibitor-8 has shown potential in preclinical studies for treating various cancers, including breast, ovarian, and lung cancers, offering a promising therapeutic strategy by targeting cancer cell division and growth.