AUT1

• CAT Number: I019315
• CAS Number: 1311136-84-1
• Molecular Formula: C18H19N3O4
• Molecular Weight: 341.36
• Purity: ≥95%
• Synonyms: (5R)-5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)pyridin-3-yl]imidazolidine-2,4-dione
• InChI: InChI=1S/C18H19N3O4/c1-4-14-17(22)21(18(23)20-14)12-6-8-16(19-10-12)25-13-7-5-11(2)15(9-13)24-3/h5-10,14H,4H2,1-3H3,(H,20,23)/t14-/m1/s1
• InChIKey: AMAOXEGBJHLCSF-CQSZACIVSA-N
• SMILES: CCC1C(=O)N(C(=O)N1)C2=CN=C(C=C2)OC3=CC(=C(C=C3)C)OC

AUT1 is a recombinant human Kv3 channel modulator. AUT1 modulates Kv3.1b and Kv3.2a channels in human recombinant with pEC50 values of 5.33 and 5.31 μM, respectively. AUT1 can be used for the research of disorders associated with dysfunction of inhibitory feedback in corticolimbic circuits, such as schizophrenia[1].
AUT1 (1.5, 12.5, and 25 μM) modulates Kv3.1b and Kv3.2a channels in human recombinant with pEC50s of 5.33 and 5.31 μM, respectively[1].
AUT1 increases whole currents mediated by human Kv3.1b and Kv3.2a channels in a concentration-dependent manner[1].
AUT1 (10 and 30 μM) shifts both the voltage dependence of activation and inactivation of human Kv3.1b and Kv3.2a channels[1].
AUT1 rescues (1 and 10 μM) the fast firing of EGFP-positive cortical interneurons[1].

Reference

[1]. Rosato-Siri MD, et al. A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons. J Pharmacol Exp Ther. 2015 Sep;354(3):251-60.
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