Autogramin-2

• CAT Number: I018672
• CAS Number: 2375541-45-8
• Molecular Formula: C₂₁H₂₇N₃O₄S
• Molecular Weight: 417.52
• Purity: ≥95%
• Target: Autophagy
• Storage: -20°C
• IUPAC Name: tert-butyl 2-[(4-propan-2-yloxybenzoyl)amino]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate
• InChI: InChI=1S/C21H27N3O4S/c1-13(2)27-15-8-6-14(7-9-15)18(25)23-19-22-16-10-11-24(12-17(16)29-19)20(26)28-21(3,4)5/h6-9,13H,10-12H2,1-5H3,(H,22,23,25)
• InChIKey: PNSFNXURLSDVRV-UHFFFAOYSA-N
• SMILES: CC(C)OC1=CC=C(C=C1)C(=O)NC2=NC3=C(S2)CN(CC3)C(=O)OC(C)(C)C

Autogramin-2（Cat No.:I018672） effectively inhibits starvation-induced autophagy with IC50 of 0.27μM. Autogramin-2 also inhibits autophagy induced by Rapamycin (via inhibition of mTORC1) with IC50 of 0.14 μM. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Laraia L, et al. The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis. Nat Chem Biol. 2019 Jul;15(7):710-720.