Autophinib

• CAT Number: I013218
• CAS Number: 1644443-47-9
• Molecular Formula: C₁₄H₁₁ClN₆O₃
• Molecular Weight: 346.73
• Purity: ≥95%
• Target: Autophagy
• Solubility: DMSO: ≥ 30 mg/mL
• IUPAC Name: 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine
• InChI: InChI=1S/C14H11ClN6O3/c1-8-6-13(20-19-8)17-12-7-11(15)16-14(18-12)24-10-4-2-9(3-5-10)21(22)23/h2-7H,1H3,(H2,16,17,18,19,20)
• InChIKey: CEUMAXLRGBKFQP-UHFFFAOYSA-N
• SMILES: CC1=CC(=NN1)NC2=CC(=NC(=N2)OC3=CC=C(C=C3)[N+](=O)[O-])Cl

Autophinib (CAT: I013218) is a small molecule inhibitor that targets the protein kinase VPS34, a key regulator of the autophagy pathway. By inhibiting VPS34, Autophinib can modulate autophagy, a cellular process involved in the degradation and recycling of cellular components. Autophinib has shown potential therapeutic applications in various diseases, including cancer, neurodegenerative disorders, and infectious diseases, where dysregulation of autophagy is implicated. It is currently being studied for its pharmacological activity and therapeutic potential.

Reference

[1]. Robke L, et al. Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34. Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8153-8157.