AV-412

• CAT Number: I003592
• CAS Number: 451493-31-5
• Molecular Formula: C41H44ClFN6O7S2
• Molecular Weight: 851.41
• Purity: ≥95%
• Synonyms: N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide;4-methylbenzenesulfonic acid
• Target: Protein Tyrosine Kinase/RTK
• Solubility: 10 mM in DMSO
• Storage: Store at +4C
• IC50: 0.51 nM (EGFR L858R); 0.79 nM (EGFRT790M); 19 nM (ErbB2)
• InChI: InChI=1S/C27H28ClFN6O.2C7H8O3S/c1-5-25(36)33-23-16-20-24(30-17-31-26(20)32-19-6-7-22(29)21(28)15-19)14-18(23)8-9-27(2,3)35-12-10-34(4)11-13-35;2*1-6-2-4-7(5-3-6)11(8,9)10/h5-7,14-17H,1,10-13H2,2-4H3,(H,33,36)(H,30,31,32);2*2-5H,1H3,(H,8,9,10)
• InChIKey: GTWJVFFZCKODEV-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)(C#CC1=CC2=C(C=C1NC(=O)C=C)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)N4CCN(CC4)C

AV-412（Cat No.:I003592）is a selective, small molecule inhibitor targeting the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), two proteins involved in cancer cell growth and proliferation. It has been studied for its potential in treating various cancers, including non-small cell lung cancer (NSCLC) and breast cancer, particularly those with EGFR or HER2 mutations or overexpression. By blocking the signaling pathways mediated by these receptors, AV-412 aims to inhibit tumor growth and improve treatment outcomes. Clinical trials are ongoing to assess its safety, efficacy, and optimal therapeutic use.