Avatrombopag maleate

• CAT Number: I022707
• CAS Number: 677007-74-8
• Molecular Formula: C33H38Cl2N6O7S2
• Molecular Weight: 765.72
• Purity: 98%
• Synonyms: AKR501; AKR 501; AKR-501; YM477; YM-477; YM 477; AS 1670542; AS1670542; AS-1670542; E5501; E-5501; E 5501; Avatrombopag; Avatrombopag maleate.
• Target: Thrombopoietin Receptor
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (Z)-but-2-enedioic acid;1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid
• InChI: InChI=1S/C29H34Cl2N6O3S2.C4H4O4/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40;5-3(6)1-2-4(7)8/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38);1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChIKey: MISPBGHDNZYFNM-BTJKTKAUSA-N
• SMILES: C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl.C(=C\C(=O)O)\C(=O)O

Avatrombopag maleate（Cat No.:I022707）is a thrombopoietin receptor agonist used to treat thrombocytopenia (low platelet count) in patients with chronic liver disease or those undergoing certain medical treatments, such as chemotherapy. It works by stimulating the thrombopoietin receptor, leading to increased production of platelets from the bone marrow. Avatrombopag is typically used in patients with liver cirrhosis to reduce the risk of bleeding before procedures. It is administered orally and has been shown to be effective in raising platelet counts while maintaining a favorable safety profile. Ongoing studies explore its use in other thrombocytopenia-related conditions.