For research use only. Not for therapeutic Use.
AVE5688（Cat No.:I020286） is an inhibitor of glycogen phosphorylase (GP), demonstrating inhibitory effects on rabbit muscle glycogen phosphorylase (rmGPb and rmGPa). It exhibits IC50 values of 430 nM and 915 nM and Kd values of 170 nM and 530 nM for rmGPb and rmGPa, respectively. AVE5688 holds potential for research related to type 2 diabetes, as targeting GP activity can help regulate glucose metabolism and glycogen breakdown.
| Catalog Number | I020286 |
| CAS Number | 613260-13-2 |
| Molecular Formula | C₁₆H₈ClF₅N₂O₅ |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | 4-[(2-chloro-4,5-difluorobenzoyl)carbamoylamino]-3-(trifluoromethoxy)benzoic acid |
| InChI | InChI=1S/C16H8ClF5N2O5/c17-8-5-10(19)9(18)4-7(8)13(25)24-15(28)23-11-2-1-6(14(26)27)3-12(11)29-16(20,21)22/h1-5H,(H,26,27)(H2,23,24,25,28) |
| InChIKey | NWQGDIBCFLDHDO-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1C(=O)O)OC(F)(F)F)NC(=O)NC(=O)C2=CC(=C(C=C2Cl)F)F |
| Reference | [1]. Anderka O, et al. Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. Biochemistry. 2008 Apr 22;47(16):4683-91. |
