For research use only. Not for therapeutic Use.
Avotaciclib hydrochloride is the hydrochloride form of Avotaciclib (HY-137432), a CDK1 inhibitor. Avotaciclib hydrochloride can be used for a few specific cancers, such as pancreatic cancer, in which CDK1 is abnormal and strongly expressed[1].
| Catalog Number | I041014 |
| Synonyms | 2,6-bis(2-aminopyrimidin-4-yl)pyridin-3-ol;hydrochloride |
| Molecular Formula | C13H12ClN7O |
| Purity | ≥95% |
| InChI | InChI=1S/C13H11N7O.ClH/c14-12-16-5-3-8(19-12)7-1-2-10(21)11(18-7)9-4-6-17-13(15)20-9;/h1-6,21H,(H2,14,16,19)(H2,15,17,20);1H |
| InChIKey | ZONRGCMBLZETKM-UHFFFAOYSA-N |
| SMILES | C1=CC(=NC(=C1O)C2=NC(=NC=C2)N)C3=NC(=NC=C3)N.Cl |
| Reference | [1]. Xie Z, et al. Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts. J Med Chem. 2022 May 12;65(9):6356-6389. |
