AWZ1066S

• CAT Number: I019452
• CAS Number: 2239272-16-1
• Molecular Formula: C₁₉H₁₉F₃N₆O
• Molecular Weight: 404.39
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 2-[(3S)-3-methylmorpholin-4-yl]-N-[[2-(trifluoromethyl)pyridin-3-yl]methyl]pyrido[2,3-d]pyrimidin-4-amine
• InChI: InChI=1S/C19H19F3N6O/c1-12-11-29-9-8-28(12)18-26-16-14(5-3-7-24-16)17(27-18)25-10-13-4-2-6-23-15(13)19(20,21)22/h2-7,12H,8-11H2,1H3,(H,24,25,26,27)/t12-/m0/s1
• InChIKey: IZFVCNUAPFSNCO-LBPRGKRZSA-N
• SMILES: C[C@H]1COCCN1C2=NC3=C(C=CC=N3)C(=N2)NCC4=C(N=CC=C4)C(F)(F)F

AWZ1066S（Cat No.:I019452）is a promising drug candidate designed to target Wolbachia, a bacterium residing within filarial parasites. It demonstrates high specificity in its action against Wolbachia, making it a potential treatment for filariasis, a debilitating parasitic disease. AWZ1066S exhibits a remarkable EC50 (half-maximal effective concentration) of 2.5 nM in cell assays, indicating its potent activity against Wolbachia. This drug holds potential for the short-course treatment of filariasis, offering hope for improved therapeutic options and potential elimination of the disease in affected populations.

Reference

[1]. Hong WD, et al. AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1414-1419.