For research use only. Not for therapeutic Use.
AX-024（Cat No.:I013060） is a cytokine release inhibitor that demonstrates strong inhibition of several key cytokines. It effectively suppresses the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10, and IL-17A. By inhibiting the release of these cytokines, AX-024 may have potential applications in modulating immune responses and managing conditions associated with excessive cytokine production.
| Catalog Number | I013060 |
| CAS Number | 1370544-73-2 |
| Molecular Formula | C₂₁H₂₂FNO₂ |
| Purity | ≥95% |
| Target | IFNARInterleukin RelatedTNF-alpha |
| Solubility | DMSO: 35 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 1-[[4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl]pyrrolidine |
| InChI | InChI=1S/C21H22FNO2/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23/h4-9,12H,2-3,10-11,13-14H2,1H3 |
| InChIKey | VMMKGVRPILDZML-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=C1)OCC(=C2C3=CC=C(C=C3)F)CN4CCCC4 |
| Reference | [1]. Borroto A, et al. First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci Transl Med. 2016 Dec 21;8(370):370ra184. |
