AZ-003

• CAT Number: I022785
• Molecular Formula: C11H11N3S
• Molecular Weight: 217.29
• Purity: 98%
• Synonyms: AZ-003; AZ 003; AZ003
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 5-amino-4-phenylthiophene-2-carboximidamide
• InChI: InChI=1S/C11H11N3S/c12-10(13)9-6-8(11(14)15-9)7-4-2-1-3-5-7/h1-6H,14H2,(H3,12,13)
• InChIKey: GRKPPKGSYOWFQV-UHFFFAOYSA-N
• SMILES: NC1=C(C=C(C(N)=N)S1)C2=CC=CC=C2

AZ-003 (Cat No.: I022785) is a potent and selective small-molecule inhibitor targeting inflammation and immune-related pathways. Designed for immunology and inflammation research, AZ-003 modulates key signaling cascades involved in immune cell activation, cytokine release, and inflammatory responses. Its high specificity and bioavailability make it a valuable tool for studying autoimmune disorders, chronic inflammation, and related diseases. Researchers utilize AZ-003 to investigate therapeutic strategies for conditions such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. Its efficacy and stability ensure reliable experimental outcomes.

Reference

1: Guillory X, Wolter M, Leysen S, et al. Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J Med Chem. 2020;63(13):6694-6707. doi:10.1021/acs.jmedchem.9b01942