For research use only. Not for therapeutic Use.
AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC50 of 7 nM[1].
AZ-Dyrk1B-33 shows inhibition of phosphorylation of Dyrk pS421 in cells with an IC50 of 0.192 μM[1].
AZ-Dyrk1B-33 shows no effect in sensitization[1].
| Catalog Number | I011262 |
| CAS Number | 1679330-37-0 |
| Synonyms | 1-benzyl-3-(2-methylpyrimidin-4-yl)pyrrolo[2,3-c]pyridine |
| Molecular Formula | C19H16N4 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H16N4/c1-14-21-10-8-18(22-14)17-13-23(12-15-5-3-2-4-6-15)19-11-20-9-7-16(17)19/h2-11,13H,12H2,1H3 |
| InChIKey | CZCUSHJQJWKYTD-UHFFFAOYSA-N |
| SMILES | CC1=NC=CC(=N1)C2=CN(C3=C2C=CN=C3)CC4=CC=CC=C4 |
| Reference | [1]. Kettle JG, et al. Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem. 2015 Mar 26;58(6):2834-44. |
