AZ-GHS-22

• CAT Number: I022904
• CAS Number: 1143020-91-0
• Molecular Formula: C27H33ClN6O5S2
• Molecular Weight: 621.17
• Purity: ≥95%
• IUPAC Name: 2-chloro-N-[[6-[3-(4-methylpiperazin-1-yl)propylsulfonyl]-1,3-benzothiazol-2-yl]carbamoyl]-5-morpholin-4-ylbenzamide
• InChI: InChI=1S/C27H33ClN6O5S2/c1-32-8-10-33(11-9-32)7-2-16-41(37,38)20-4-6-23-24(18-20)40-27(29-23)31-26(36)30-25(35)21-17-19(3-5-22(21)28)34-12-14-39-15-13-34/h3-6,17-18H,2,7-16H2,1H3,(H2,29,30,31,35,36)
• SMILES: CN1CCN(CC1)CCCS(=O)(=O)C2=CC3=C(C=C2)N=C(S3)NC(=O)NC(=O)C4=C(C=CC(=C4)N5CCOCC5)Cl

Orally available high affinity Ghrelin receptor (GHS-R1a) inverse agonist (IC50 0.77 nM) with very low CNS exposure.
KEYWORDS: AZ-GHS-22 | supplier | GHS-R1a inverse agonist | AZGHS22 | CAS [1143020-91-0] | Metabolism | GHSR | Inverse agonist | Ghrelin | CNS | food | intake | metabolism | brain penetrant

Reference

W. McCoull et al. Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. J Med Chem. 2014 Jul 24;57(14):6128-40. doi: 10.1021/jm500610n. Epub 2014 Jul 8.