AZ10397767

• CAT Number: I003353
• CAS Number: 333742-63-5
• Molecular Formula: C15H14ClFN4O2S2
• Molecular Weight: 400.87
• Purity: ≥95%
• Synonyms: AZ-10397767; AZ 10397767; AZ10397767.;5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one
• Target: Immunology/Inflammation
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term or -20 °C for long term
• IC50: IC50 = 1 nM
• IUPAC Name: 5-[(3-chloro-2-fluorophenyl)methylsulfanyl]-7-[[(2R)-1-hydroxypropan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
• InChI: InChI=1S/C15H14ClFN4O2S2/c1-7(5-22)18-12-11-13(21-15(23)25-11)20-14(19-12)24-6-8-3-2-4-9(16)10(8)17/h2-4,7,22H,5-6H2,1H3,(H2,18,19,20,21,23)/t7-/m1/s1
• InChIKey: KHTUORKUWBDRBX-SSDOTTSWSA-N
• SMILES: CC(CO)NC1=NC(=NC2=C1SC(=O)N2)SCC3=C(C(=CC=C3)Cl)F

AZ10397767(CAT: I003353) is a highly potent CXCR2 antagonist with an IC50 of 1 nM, widely utilized in cancer and inflammation research. By blocking CXCR2, it effectively reduces neutrophil infiltration in both in vitro and in vivo tumor models, contributing to slower tumor growth. This compound also enhances the efficacy of co-administered therapies, such as 17-AAG, by modulating the tumor microenvironment. AZ10397767 is an invaluable tool for studying CXCR2-mediated pathways, immune modulation, and the development of combination therapies targeting tumor progression and inflammatory responses.