AZ12971554

• CAT Number: I003388
• CAS Number: 1201686-45-4
• Molecular Formula: C20H17ClFN7O3
• Molecular Weight: 457.85
• Purity: ≥95%
• Synonyms: AZ12971554 ; AZ-12971554; AZ 12971554.;(5S)-N-{[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]methyl}-1-[(2R)-2-(4-fluorophenyl)-2-hydroxyacetyl]-4,5-dihydro-1H-pyrazole-5-carboxamide
• Target: Human Thrombin Inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term or -20 °C for long term
• IUPAC Name: (3S)-N-[[5-chloro-2-(tetrazol-1-yl)phenyl]methyl]-2-[(2R)-2-(4-fluorophenyl)-2-hydroxyacetyl]-3,4-dihydropyrazole-3-carboxamide
• InChI: InChI=1S/C20H17ClFN7O3/c21-14-3-6-16(28-11-24-26-27-28)13(9-14)10-23-19(31)17-7-8-25-29(17)20(32)18(30)12-1-4-15(22)5-2-12/h1-6,8-9,11,17-18,30H,7,10H2,(H,23,31)/t17-,18+/m0/s1
• InChIKey: GMKHQRCPNMGCIX-ZWKOTPCHSA-N
• SMILES: C1C=NN([C@@H]1C(=O)NCC2=C(C=CC(=C2)Cl)N3C=NN=N3)C(=O)[C@@H](C4=CC=C(C=C4)F)O

AZ12971554（Cat No.:I003388）is a chemical compound identified as a selective inhibitor of certain kinases, specifically targeting the protein kinase TBK1 (TANK-binding kinase 1) and IKKε (IκB kinase epsilon). These kinases play critical roles in regulating immune responses and inflammatory pathways. By inhibiting TBK1 and IKKε, AZ12971554 has potential therapeutic applications in treating inflammatory diseases, autoimmune disorders, and certain types of cancer. Additionally, the compound has been investigated in the context of neurodegenerative diseases, where excessive activation of these kinases may contribute to disease progression. Further research continues to explore its efficacy and safety.

Reference

1. Karlsson S, Branalt J, Halvarsson MO, Bergman J. (2014) A One-Pot Asymmetric Synthesis of a N Acylated 4,5- Dihydropyrazole, A Key Intermediate of Thrombin Inhibitor AZD8165. Organic Process Research and Development, 18: 969-975.