AZ191

• CAT Number: I002019
• CAS Number: 1594092-37-1
• Molecular Formula: C24H27N7O
• Molecular Weight: 429.5
• Purity: ≥95%
• Synonyms: N-​[2-​methoxy-​4-​(4-​methyl-​1-​piperazinyl)​phenyl]​-​4-​(1-​methyl-​1H-​pyrrolo[2,​3-​c]​pyridin-​3-​yl)​-2-​pyrimidinamine
• Target: DYRK
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: -20°C
• IC50: 17 nM [1]
• IUPAC Name: N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine
• InChI: InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)
• InChIKey: ZYVXTMKTGDARKR-UHFFFAOYSA-N
• SMILES: CN1CCN(C2=CC=C(NC3=NC=CC(C4=CN(C)C5=C4C=CN=C5)=N3)C(OC)=C2)CC1

AZ191(CAT: I002019) is a potent and selective small-molecule inhibitor targeting DYRK1B, with an IC50 of 17 nM. It demonstrates high specificity for DYRK1B over related kinases such as DYRK1A and DYRK2, making it an essential tool for studying DYRK1B-mediated signaling pathways. This compound is widely used in research focusing on cell cycle regulation, metabolic disorders, and cancer, where DYRK1B plays a pivotal role. Its high purity and consistent performance ensure reliable experimental outcomes, supporting investigations into therapeutic strategies involving DYRK1B inhibition. AZ191 is ideal for advancing research in kinase biology and drug discovery.