For research use only. Not for therapeutic Use.
AZ2 is a highly selective PI3Kγ inhibitor (The pIC50 value for PI3Kγ is 9.3). AZ2 can be used for the research of inflammatory and immune diseases[1].
AZ2 (0.1~100 nM; 1 hour; SKOV-3 cells) excellent selectivity for PI3Kγ is further confirmed with a constitutively activated PI3K/Akt pathway[1].
| Catalog Number | I045626 |
| CAS Number | 2231760-33-9 |
| Synonyms | N-[5-[2-[(1S)-1-cyclopropylethyl]-7-methyl-1-oxo-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]acetamide |
| Molecular Formula | C20H23N3O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H23N3O2S/c1-10-7-15(18-11(2)21-20(26-18)22-13(4)24)8-16-9-23(19(25)17(10)16)12(3)14-5-6-14/h7-8,12,14H,5-6,9H2,1-4H3,(H,21,22,24)/t12-/m0/s1 |
| InChIKey | CNCRCDLWUGCPSJ-LBPRGKRZSA-N |
| SMILES | CC1=CC(=CC2=C1C(=O)N(C2)C(C)C3CC3)C4=C(N=C(S4)NC(=O)C)C |
| Reference | [1]. Gangadhara G, et al. A class of highly selective inhibitors bind to an active state of PI3Kγ. Nat Chem Biol. 2019;15(4):348-357. |
