For research use only. Not for therapeutic Use.
AZ876(CAT: I005380) is a novel and high-affinity agonist of liver X receptors (LXRs). LXRs are nuclear receptors that play a crucial role in regulating lipid metabolism, inflammation, and cholesterol homeostasis. AZ876 has been found to activate both human LXRα and LXRβ with high potency. In comparison to the widely used LXR agonist GW3965 (CAS number HY-10627), AZ876 demonstrates greater potency in its activation of human LXRα by approximately 25-fold and human LXRβ by approximately 2.5-fold.
| Catalog Number | I005380 |
| CAS Number | 898800-26-5 |
| Molecular Formula | C24H29N3O3S |
| Purity | ≥95% |
| Target | liver X receptor agonist |
| Solubility | DMSO: ≥ 2.6 mg/mL |
| Storage | -20°C |
| IUPAC Name | 2-tert-butyl-1,1-dioxo-5-phenyl-4-(4-piperidin-1-ylanilino)-1,2-thiazol-3-one |
| InChI | InChI=1S/C24H29N3O3S/c1-24(2,3)27-23(28)21(22(31(27,29)30)18-10-6-4-7-11-18)25-19-12-14-20(15-13-19)26-16-8-5-9-17-26/h4,6-7,10-15,25H,5,8-9,16-17H2,1-3H3 |
| InChIKey | IVANYIPLGFVBGR-UHFFFAOYSA-N |
| SMILES | CC(C)(C)N1C(=O)C(=C(S1(=O)=O)C2=CC=CC=C2)NC3=CC=C(C=C3)N4CCCCC4 |
| Reference | </br>1:The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects. Cannon MV, Yu H, Candido WM, Dokter MM, Lindstedt EL, Silljé HH, van Gilst WH, de Boer RA.Eur J Heart Fail. 2015 Mar;17(3):273-82. doi: 10.1002/ejhf.243. Epub 2015 Feb 11. PMID: 25684370 Free Article</br>2:Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. van der Hoorn J, Lindén D, Lindahl U, Bekkers M, Voskuilen M, Nilsson R, Oscarsson J, Lindstedt E, Princen H.Br J Pharmacol. 2011 Apr;162(7):1553-63. doi: 10.1111/j.1476-5381.2010.01168.x. PMID: 21175581 Free PMC Article |
