AZA1

For research use only. Not for therapeutic Use.

  • CAT Number: I015208
  • CAS Number: 1071098-42-4
  • Molecular Formula: C₂₂H₂₀N₆
  • Molecular Weight: 368.43
  • Purity: ≥95%
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AZA1 (Azaspiracid-1)(Cat No.:I015208)is a marine toxin produced by certain species of dinoflagellates, primarily found in shellfish contaminated by toxic algal blooms. It is responsible for azaspiracid poisoning (AZP) in humans, characterized by symptoms such as gastrointestinal distress, including nausea, vomiting, and diarrhea. AZA1 disrupts cellular processes by interfering with ion channels and signal transduction pathways, making it a subject of interest in toxicology and marine biology research. Studies focus on understanding its mechanisms of toxicity, detection methods, and the impact on seafood safety and public health.

Catalog Number I015208
CAS Number 1071098-42-4
Molecular Formula C₂₂H₂₀N₆
Purity ≥95%
IUPAC Name 2-N,4-N-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine
InChI InChI=1S/C22H20N6/c1-13-9-15-11-17(3-5-19(15)24-13)26-21-7-8-23-22(28-21)27-18-4-6-20-16(12-18)10-14(2)25-20/h3-12,24-25H,1-2H3,(H2,23,26,27,28)
InChIKey SYWHWWKOIJCMKF-UHFFFAOYSA-N
SMILES CC1=CC2=C(N1)C=CC(=C2)NC3=NC(=NC=C3)NC4=CC5=C(C=C4)NC(=C5)C
Reference

[1]. Zins K, et al. A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice. PLoS One. 2013;8(9):e74924. Published 2013 Sep 11.<br>[2]. Suzuki O, et al. Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family. Int J Oncol. 2015;47(6):2091‐2099.

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