For research use only. Not for therapeutic Use.
Azacyclonol (γ-pipradol), a metabolite of Terfenadine, is a central depressant agent. Azacyclonol is a ganglion-blocking agent. Azacyclonol can be used to diminish psychoses-induced hallucinations[1][2][3].
Azacyclonol is formed from Terfenadine in rat liver[2].
Azacyclonol causes depressed activity in mice and rats[3].
Azacyclonol antagonizes increased coordination activity in mice induced by pipradrol, amphetamine, morphine and cocaine and prolongs Hexobarbital hypnosis[3].
| Catalog Number | A000182 |
| CAS Number | 115-46-8 |
| Synonyms | diphenyl(piperidin-4-yl)methanol |
| Molecular Formula | C18H21NO |
| Purity | ≥95% |
| InChI | InChI=1S/C18H21NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17,19-20H,11-14H2 |
| InChIKey | ZMISODWVFHHWNR-UHFFFAOYSA-N |
| SMILES | C1CNCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)O |
| Reference | [1]. Brown DA, et, al. The effects of some centrally acting drugs on ganglionic transmission in the cat. [2]. Jurima-Romet M, et, al. Induction of CYP3A and associated terfenadine N-dealkylation in rat hepatocytes cocultured with 3T3 cells. Cell Biol Toxicol. 1995 Dec;11(6):313-27. [3]. BRAUN DL, et, al. The pharmacologic activity of alpha-(4-piperidyl)-benzhydrol hydrochloride (azacyclonol hydrochloride); an ataractive agent. J Pharmacol Exp Ther. 1956 Oct;118(2):153-61. |
