For research use only. Not for therapeutic Use.
Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin.
IC50 Value:
Target: SSRIs
Pipofezine is a tricyclic antidepressant (TCA) approved in Russia for the treatment ofdepression.
| Catalog Number | I004387 |
| CAS Number | 63302-99-8 |
| Synonyms | 5-methyl-3-(4-methylpiperazin-1-yl)pyridazino[3,4-b][1,4]benzoxazine;hydrate;dihydrochloride |
| Molecular Formula | C16H23Cl2N5O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H19N5O.2ClH.H2O/c1-19-7-9-21(10-8-19)15-11-13-16(18-17-15)22-14-6-4-3-5-12(14)20(13)2;;;/h3-6,11H,7-10H2,1-2H3;2*1H;1H2 |
| InChIKey | VKMOGSQJNTXLNA-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=NN=C3C(=C2)N(C4=CC=CC=C4O3)C.O.Cl.Cl |
| Reference | [1]. Shinaev NN, Akzhigitov RG. Azaphen: a return to clinical practice.Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(10):55-6. [2]. Ignatowicz L, Ignatowicz R, Wdowiak MW, Jaremko A. Azaphen in the treatment of enuresis in children.Psychiatr Pol. 1977 Jan-Feb;11(1):29-33. [3]. Liberman SS, Sharova SA. A comparison of the effect of the tricyclic antidepressants azaphen and imizin on the gastrointestinal tracts of experimental animals.Farmakol Toksikol. 1975 Jan-Feb;38(1):29-32. [4]. Misurec J, Náhunek K, Kamenická V, Chmelar M. Proceedings: Influence of azaphen, a new antidepressive drug, on the human EEG. Act Nerv Super (Praha). 1974;16(4):245-6. |
