For research use only. Not for therapeutic Use.
Azapropazone, also known as Rheumox and AHR-3018, is anti-inflammatory agent with reported uricosuric properties used to treat rheumatoid arthritis and ankylosing spondylitis. Azapropazone lowered plasma uric acid but exerted only a modest and variable uricosuric effect without altering urinary xanthine and hypoxanthine levels.
| Catalog Number | M065347 |
| CAS Number | 13539-59-8 |
| Molecular Formula | C16H20N4O2 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione |
| InChI | InChI=1S/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22/h7-9,11H,5-6H2,1-4H3 |
| InChIKey | MPHPHYZQRGLTBO-UHFFFAOYSA-N |
| SMILES | CCCC1C(=O)N2C3=C(C=CC(=C3)C)N=C(N2C1=O)N(C)C |
| Reference | </br>1:Azapropazone in aspirin intolerance. Gutgesell C, Fuchs T.Allergy. 1999 Aug;54(8):897-8. No abstract available. PMID: 10485401 Free Article</br>2:Effects of azapropazone on pain-related brain activity in human subjects. Lötsch J, Mohammadian P, Hummel T, Florin S, Brune K, Geisslinger G, Kobal G.Br J Clin Pharmacol. 1995 Dec;40(6):545-52. PMID: 8703660 Free PMC Article</br>3:Inefficacy of azapropazone in the acute arthritis of Behçet/’s syndrome: a randomized, double blind, placebo controlled study. Moral F, Hamuryudan V, Yurdakul S, Yazici H.Clin Exp Rheumatol. 1995 Jul-Aug;13(4):493-5. PMID: 7586783 </br>4:Positive interference by azapropazone (Rheumox) in the measurement of total thyroxine using the Ciba-Corning ACS:180 immunoassay analyser. Smart JM, Caslake C, Gunn I.Ann Clin Biochem. 1995 Jul;32 ( Pt 4):424-5. No abstract available. PMID: 7486806 </br>5:Lack of activity of azapropazone in the hot-plate test and in 5-HT1A and 5-HT2 receptor subtypes in rat brain membranes. Pini LA, Sandrini M, Vitale G.Drugs Exp Clin Res. 1995;21(5):181-6. PMID: 8846748 </br>6:Effects on platelet functions and pharmacokinetics of azapropazone and ketorolac tromethamine given as single parenteral doses. Pallapies D, Peskar BA, Brune K, Geisslinger G.Br J Clin Pharmacol. 1994 Apr;37(4):335-9. PMID: 8018454 Free PMC Article</br>7:Photoproducts of benzydamine and azapropazone: demonstration of their phototoxicity in vitro. Vargas F, Rivas C, Machado R, Sarabia Z, López I.J Photochem Photobiol B. 1993 Jan;17(1):41-5. PMID: 8433222 </br>8:A new approach to encapsulating non-steroidal anti-inflammatory drugs. V. Biopharmaceutical study of microcapsules of azapropazone coated with pectin and rutin. Meshali MM, el-Dien EZ, Omar SA, Luzzi LA.J Microencapsul. 1992 Jan-Mar;9(1):67-72. PMID: 1613645 </br>9:A controlled trial of azapropazone in tinnitus. Stoney PJ, Callaghan DE, Walker FS, Stephens SD.Br J Audiol. 1991 Dec;25(6):415-7. PMID: 1773202 </br>10:A comparison of azapropazone and aspirin for pain relief following dental extractions. Garrioch MA, Wardall GJ, Fitch W.Anaesthesia. 1991 Oct;46(10):828-32. PMID: 1842215 Free Article |
