For research use only. Not for therapeutic Use.
Azathioprine (Cat No.: I003581) is one of the derivatives of the chemical compound 6-mercaptopurine, which belongs to immunosuppressive drugs. It is a derivative of mercaptopurine, which can be decomposed into mercaptopurine in the body to work. It is mainly used to suppress immune rejection during allogeneic transplantation, and it is mostly used in combination with corticosteroids.
| Catalog Number | I003581 |
| CAS Number | 446-86-6 |
| Synonyms | 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine |
| Molecular Formula | C9H7N7O2S |
| Purity | ≥95% |
| Target | DNA Synthesis |
| Solubility | DMSO 55 mg/mL; Water <1 mg/mL |
| Storage | 2-8°C |
| IUPAC Name | 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine |
| InChI | InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13) |
| InChIKey | LMEKQMALGUDUQG-UHFFFAOYSA-N |
| SMILES | CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-] |
| Reference | </br>1:Azathioprine Therapy and <i>TPMT</i> Genotype. Dean L.In: Pratt V, McLeod H, Dean L, Malheiro A, Rubinstein W, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012-.2012 Sep 20 [updated 2016 May 3]. PMID: 28520349 Free Books & Documents</br>2:Azathioprine allows glucocorticoid withdrawal – post hoc results of a prospective study in patients with inflammatory bowel diseases. Teich N, Mohl W, Bokemeyer B, Bündgens B, Büning J, Miehlke S, Hüppe D, Maaser C, Siegmund B, Schmidt C, Stallmach A; German IBD Study group..Z Gastroenterol. 2017 May;55(5):461-465. doi: 10.1055/s-0043-106310. Epub 2017 May 12. PMID: 28499322 </br>3:An open, multicenter, randomized clinical study in patients with bullous pemphigoid comparing methylprednisolone and azathioprine with methylprednisolone and dapsone. Sticherling M, Franke A, Aberer E, Gläser R, Hertl M, Pfeiffer C, Rzany B, Schneider S, Shimanovich I, Werfel T, Wilczek A, Zillikens D, Schmidt E.Br J Dermatol. 2017 May 11. doi: 10.1111/bjd.15649. [Epub ahead of print] PMID: 28494097 </br>4:Eruptive melanocytic nevi during azathioprine therapy for antisynthetase syndrome. Steinweg SA, Halvorson CR, Kao GF, Dronavalli S.Cutis. 2017 Apr;99(4):268-270. PMID: 28492593 </br>5:Azathioprine combination therapy for steroid-refractory hepatic immune system-related adverse events. Iwamoto K, Ishitsuka Y, Tanaka R, Sekine I, Fujimoto M.Eur J Dermatol. 2017 May 3. doi: 10.1684/ejd.2017.2973. [Epub ahead of print] No abstract available. PMID: 28468733 </br>6:Azathioprine with Allopurinol: Lower Deoxythioguanosine in DNA and Transcriptome Changes Indicate Mechanistic Differences to Azathioprine Alone. Coulthard SA, Berry P, McGarrity S, McLaughlin S, Ansari A, Redfern CPF.Inflamm Bowel Dis. 2017 Jun;23(6):946-955. doi: 10.1097/MIB.0000000000001131. PMID: 28452864 </br>7:Enteric-coated mycophenolate sodium versus azathioprine in patients with active systemic lupus erythematosus: a randomised clinical trial. Ordi-Ros J, Sáez-Comet L, Pérez-Conesa M, Vidal X, Mitjavila F, Castro Salomó A, Cuquet Pedragosa J, Ortiz-Santamaria V, Mauri Plana M, Cortés-Hernández J.Ann Rheum Dis. 2017 Apr 27. pii: annrheumdis-2016-210882. doi: 10.1136/annrheumdis-2016-210882. [Epub ahead of print] PMID: 28450313 </br>8:Azathioprine dose reduction in inflammatory bowel disease patients on combination therapy: an open-label, prospective and randomised clinical trial. Roblin X, Boschetti G, Williet N, Nancey S, Marotte H, Berger A, Phelip JM, Peyrin-Biroulet L, Colombel JF, Del Tedesco E, Paul S, Flourie B.Aliment Pharmacol Ther. 2017 Apr 27. doi: 10.1111/apt.14106. [Epub ahead of print] PMID: 28449228 </br>9:Azathioprine Maintenance Therapy to Prevent Relapses in Autoimmune Pancreatitis. de Pretis N, Amodio A, Bernardoni L, Campagnola P, Capuano F, Chari ST, Crinò S, Gabbrielli A, Massella A, Topazian M, Frulloni L.Clin Transl Gastroenterol. 2017 Apr 27;8(4):e90. doi: 10.1038/ctg.2017.17. PMID: 28448071 </br>10:Azathioprine, Mercaptopurine, and 5-Aminosalicylic Acid Affect the Growth of IBD-Associated <i>Campylobacter</i> Species and Other Enteric Microbes. Liu F, Ma R, Riordan SM, Grimm MC, Liu L, Wang Y, Zhang L.Front Microbiol. 2017 Mar 29;8:527. doi: 10.3389/fmicb.2017.00527. eCollection 2017. PMID: 28424670 Free PMC Article |
