For research use only. Not for therapeutic Use.
AZD0364（Cat No.:I020262）, also known as ATG-017, is a potent inhibitor of ERK1/2, a key signaling pathway involved in cell growth and proliferation. It exhibits a high degree of selectivity towards ERK2 with an IC50 of 0.6 nM. By inhibiting ERK1/2, AZD0364 disrupts the signaling cascade, preventing aberrant cell growth and proliferation associated with various diseases, including cancer. This compound holds promise as a targeted therapeutic option for conditions driven by dysregulated ERK1/2 signaling and may contribute to the development of more effective treatments for cancer and other related disorders.
| Catalog Number | I020262 |
| CAS Number | 2097416-76-5 |
| Molecular Formula | C₂₄H₂₄F₂N₈O₂ |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | (6R)-7-[(3,4-difluorophenyl)methyl]-6-(methoxymethyl)-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5,6-dihydroimidazo[1,2-a]pyrazin-8-one |
| InChI | InChI=1S/C24H24F2N8O2/c1-14-9-27-24(30-20-6-7-28-32(20)2)31-21(14)19-12-33-11-16(13-36-3)34(23(35)22(33)29-19)10-15-4-5-17(25)18(26)8-15/h4-9,12,16H,10-11,13H2,1-3H3,(H,27,30,31)/t16-/m1/s1 |
| InChIKey | HVIGNZUDBVLTLU-MRXNPFEDSA-N |
| SMILES | CC1=CN=C(N=C1C2=CN3CC(N(C(=O)C3=N2)CC4=CC(=C(C=C4)F)F)COC)NC5=CC=NN5C |
| Reference | [1]. WARD, Richard, Andrew, et al. DIHYDROIMIDAZOPYRAZINONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER. WO2017080979A1. |
