AZD-1678

• CAT Number: I022853
• CAS Number: 942137-41-9
• Molecular Formula: C11H8Cl2FN3O3S
• Molecular Weight: 352.17
• Purity: ≥95%
• Synonyms: 2,3-dichloro-N-(5-fluoro-3-methoxypyrazin-2-yl)benzenesulfonamide
• InChI: InChI=1S/C11H8Cl2FN3O3S/c1-20-11-10(15-5-8(14)16-11)17-21(18,19)7-4-2-3-6(12)9(7)13/h2-5H,1H3,(H,15,17)
• InChIKey: NWSUDJQTTGDPIR-UHFFFAOYSA-N
• SMILES: COC1=NC(=CN=C1NS(=O)(=O)C2=C(C(=CC=C2)Cl)Cl)F

AZD-1678 is a potent CCR4 receptor antagonist, with a pIC50 of 8.6[1].

Reference

[1]. Nicholas Kindon, et al. Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986.
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