For research use only. Not for therapeutic Use.
AZD3759 (Cat No.: I002094) is an investigational, orally bioavailable epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) developed by AstraZeneca. It is designed to effectively penetrate the blood-brain barrier, targeting EGFR-mutated non-small cell lung cancer (NSCLC) with central nervous system (CNS) metastases. AZD-3759 selectively inhibits mutant EGFR signaling, suppressing tumor growth both systemically and in the brain. Preclinical and early clinical studies demonstrated promising CNS activity, making it a potential therapeutic candidate for treating EGFR-driven brain metastases in lung cancer patients.
CAS Number | 1626387-80-1 |
Synonyms | AZD3759; (2R)-2,4-dimethyl-1-piperazinecarboxylic acid-4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester |
Molecular Formula | C₂₂H₂₃ClFN₅O₃ |
Purity | ≥95% |
Target | Protein Tyrosine Kinase/RTK |
Solubility | 10 mM in DMSO |
Storage | -20°C |
Overview of Clinical Research | Originator: AstraZeneca<br /> |
IC50 | 7.2 nM (L858R pEGFR) |
InChI | InChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H,25,26,27)/t13-/m1/s1 |
InChIKey | MXDSJQHFFDGFDK-CYBMUJFWSA-N |
SMILES | CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C |
Reference | 1: Ahn MJ, Kim DW, Cho BC, Kim SW, Lee JS, Ahn JS, Kim TM, Lin CC, Kim HR, John <br> <br> <br> 5: Zeng Q, Wang J, Cheng Z, Chen K, Johnström P, Varnäs K, Li DY, Yang ZF, Zhang |
Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |