For research use only. Not for therapeutic Use.
AZD-4818 is a potent antagonist of chemokine CCR1. AZD-4818 can be used for researching chronic obstructive pulmonary disease (COPD) [1].
| Catalog Number | I003661 |
| CAS Number | 1003566-93-5 |
| Synonyms | 2-[2-chloro-5-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4′-piperidine]-1′-yl)-2-hydroxypropoxy]-4-(methylcarbamoyl)phenoxy]-2-methylpropanoic acid |
| Molecular Formula | C27H32Cl2N2O7 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H32Cl2N2O7/c1-26(2,25(34)35)37-23-12-22(19(11-20(23)29)24(33)30-3)36-15-18(32)14-31-8-6-27(7-9-31)13-16-10-17(28)4-5-21(16)38-27/h4-5,10-12,18,32H,6-9,13-15H2,1-3H3,(H,30,33)(H,34,35)/t18-/m0/s1 |
| InChIKey | HVTUHSABWJPWNK-SFHVURJKSA-N |
| SMILES | CC(C)(C(=O)O)OC1=C(C=C(C(=C1)OCC(CN2CCC3(CC2)CC4=C(O3)C=CC(=C4)Cl)O)C(=O)NC)Cl |
| Reference | [1]. Norman P. AZD-4818, a chemokine CCR1 antagonist: WO2008103126 and WO2009011653. Expert Opin Ther Pat. 2009;19(11):1629-1633. |
