For research use only. Not for therapeutic Use.
AZD5423 (Cat.No:I003724) is a nonsteroidal glucocorticoid by AstraZeneca used to treat respiratory diseases and in particular chronic obstructive pulmonary disease.
| Catalog Number | I003724 |
| CAS Number | 1034148-04-3 |
| Synonyms | AZD-5423; AZD 5423; AZD5423; UNII-641H0Q518W;;2,2,2-Trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)-2-propanyl)acetamide |
| Molecular Formula | C25H21F4N3O3 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at -20°C |
| IUPAC Name | 2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide |
| InChI | InChI=1S/C25H21F4N3O3/c1-15(31-24(33)25(27,28)29)23(16-4-3-5-20(12-16)34-2)35-21-10-11-22-17(13-21)14-30-32(22)19-8-6-18(26)7-9-19/h3-15,23H,1-2H3,(H,31,33)/t15-,23-/m0/s1 |
| InChIKey | FCNQMDSJHADDFT-WNSKOXEYSA-N |
| SMILES | CC(C(C1=CC(=CC=C1)OC)OC2=CC3=C(C=C2)N(N=C3)C4=CC=C(C=C4)F)NC(=O)C(F)(F)F |
| Reference | 1:Expert Opin Ther Pat. 2013 Sep;23(9):1239-45. doi: 10.1517/13543776.2013.820706. Epub 2013 Jul 19. Crystalline forms of 2,2,2-trifluoro-N-[(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-(3-methoxyphenyl)-2-propanyl]acetamide (AZD-5423).Norman P, PMID: 23865465 DOI: 10.1517/13543776.2013.820706 </br><span>Abstract:</span> A crystalline form (form B) of the novel glucocorticoid receptor agonist 2,2,2-trifluoro-N-[(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-(3-methoxyphenyl)-2-propanyl]acetamide (AZD-5423) and its use alone or in combination for the treatment of asthma and chronic obstructive pulmonary disease are claimed. This form of AZD-5423 is better absorbed than Form A drug after inhalation. Two effective large-scale syntheses of AZD-5423 are described. |
