AZD-5904

• CAT Number: I003737
• CAS Number: 618913-30-7
• Molecular Formula: C10H12N4O2S
• Molecular Weight: 252.29
• Purity: ≥95%
• Synonyms: AZ1, AZ 1 AZ-1; TX4; TX-4; TX 4; AZD-5904; AZD 5904; AZD5904.;(S)-3-((tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one
• Target: Metabolic Enzyme/Protease
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term or -20 °C for long term
• IUPAC Name: 3-[[(2R)-oxolan-2-yl]methyl]-2-sulfanylidene-7H-purin-6-one
• InChI: InChI=1S/C10H12N4O2S/c15-9-7-8(12-5-11-7)14(10(17)13-9)4-6-2-1-3-16-6/h5-6H,1-4H2,(H,11,12)(H,13,15,17)/t6-/m1/s1
• InChIKey: RSPDBEVKURKEII-ZCFIWIBFSA-N
• SMILES: C1CC(OC1)CN2C3=C(C(=O)NC2=S)NC=N3

AZD5904(CAT: I003737) is a potent and orally bioavailable inhibitor of myeloperoxidase (MPO), an enzyme predominantly found in neutrophils that contributes to the production of reactive oxygen species (ROS) during inflammatory responses. By selectively inhibiting MPO, AZD5904 reduces oxidative stress and inflammation, making it a promising therapeutic agent in conditions driven by excessive ROS production. This compound is particularly relevant in the treatment of cardiovascular diseases, neurodegenerative disorders, and autoimmune diseases, where MPO-mediated oxidative damage plays a significant role. AZD5904 is valuable in inflammation and immunology research for exploring targeted strategies to mitigate oxidative tissue injury.