For research use only. Not for therapeutic Use.
AZD-5991 (CAT: I019688) is a small-molecule inhibitor that targets the anti-apoptotic protein Mcl-1 (myeloid cell leukemia 1). Mcl-1 is a member of the Bcl-2 protein family and plays a critical role in promoting cancer cell survival by preventing apoptosis. AZD-5991 selectively binds to Mcl-1, displacing the pro-apoptotic proteins Bak and Bim, thereby promoting apoptosis in cancer cells. This inhibition of the Mcl-1 function has shown promising anti-cancer effects in preclinical studies, including both solid tumors and hematological malignancies. AZD-5991 is being investigated as a potential therapeutic option for cancer treatment, particularly in cases where elevated Mcl-1 levels contribute to treatment resistance. Clinical trials are underway to evaluate its safety and efficacy in cancer patients.
| Catalog Number | I019688 |
| CAS Number | 2143061-81-6 |
| Molecular Formula | C₃₅H₃₄ClN₅O₃S₂ |
| Purity | ≥95% |
| Target | Bcl-2 Family |
| Reference | [1]. Tron AE, et al. Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat Commun. 2018 Dec 17;9(1):5341. |
