For research use only. Not for therapeutic Use.
AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay.
| Catalog Number | I019686 |
| CAS Number | 2143061-82-7 |
| Molecular Formula | C₃₅H₃₄ClN₅O₃S₂ |
| Purity | ≥95% |
| Target | Bcl-2 Family |
| Reference | [1]. Tron AE, et al. Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat Commun. 2018 Dec 17;9(1):5341. |
