AZD-5991 (S-enantiomer)

• CAT Number: I019686
• CAS Number: 2143061-82-7
• Molecular Formula: C₃₅H₃₄ClN₅O₃S₂
• Molecular Weight: 672.26
• Purity: ≥95%
• Target: Bcl-2 Family
• IUPAC Name: 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(36),4(38),6,11,14,16,18,20,23,29(37),30,32,34-tridecaene-23-carboxylic acid
• InChI: InChI=1S/C35H34ClN5O3S2/c1-20-31-29(38-40(20)3)19-45-17-22-15-23(41(4)37-22)18-46-24-14-21-8-5-6-9-25(21)30(16-24)44-13-7-10-26-27-11-12-28(36)32(31)33(27)39(2)34(26)35(42)43/h5-6,8-9,11-12,14-16H,7,10,13,17-19H2,1-4H3,(H,42,43)
• InChIKey: KBQCEQAXHPIRTF-UHFFFAOYSA-N
• SMILES: CC1=C2C(=NN1C)CSCC3=NN(C(=C3)CSC4=CC5=CC=CC=C5C(=C4)OCCCC6=C(N(C7=C6C=CC(=C27)Cl)C)C(=O)O)C

AZD-5991 (S-enantiomer)(CAT: I019686) is a selective and potent small-molecule inhibitor of MCL-1, an anti-apoptotic protein in the BCL-2 family. By binding directly to MCL-1, it disrupts its interactions with pro-apoptotic proteins, triggering apoptosis in cancer cells reliant on MCL-1 for survival. AZD-5991 (S-enantiomer) is particularly valuable in oncology research, with potential applications in studying hematologic malignancies and solid tumors. Its high specificity and efficacy make it an important tool for exploring MCL-1 as a therapeutic target, advancing preclinical studies, and developing novel cancer treatments.